Invited workshop: Bordetella

» Publication arising from this workshop

When: March 12-13, 2005

It is rare to manage to get such a disparate group of people with a common interest into a room together. Sharing information between the different disciplines, and mutual education in the different methods and thinking processes being brought to bear on the disease, were two of the most valuable aspects of the meeting.
— Duncan Maskell, Head of Department and Marks & Spencer Professor of Farm Animal Health, Food Science & Food Safety Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge.

Objectives

The meeting brought together an international group of immunologists, evolutionary biologists, medics and modelers, to:

Identify theory to complement empirical work, and laboratory experiments to inform theoretical work
Discuss policies involving control of Bordetella species and other respiratory infections
Establish future work directions, including collaborations and involvement of other specialists

Participants

I think that this is probably the first time that a combination of people ranging from molecular biologists, through immunologists, and clinicians, to modelers, mathematicians and even a physicist, all with an interest in the same bacterial infection, have met to discuss their subject — Duncan Maskell

From L to R, top row: Mylisa Pilone, Sarah Perkins, Aaron King, Derek Johnson, Girish Kirimanjeswara, Paul Mann, James Cherry, Andrew Preston, Duncan Maskell, Bryan Grenfell, Eric Harvill
From L to R, bottom row: Pej Rohani, Jaewook Joo, Angie Luis, Kurt Vandegrift, Monica Kelly, Anne Buboltz, Eleca Dunham, Elizabeth Goebel, Peter Hudson, Ottar Bjørnstad, Réka Albert, Olivier Restif

Schedule: Friday

9:00 AM: Immunity

Bryan Grenfell and Duncan Maskell — Welcome and Introduction
Paul Mann — Innate Immunity / Differential stimulation
Girish Kirimanjeswara — Adaptive immunity / Differential sensitivity
Mylisa Pilone — Bacterial virulence factors and immune evasion / Accute vs. persistent
Reka Albert — Model synthesizing data

11:00 AM to 12:30 PM: Between host dynamics

James Cherry — Epidemiology: review of empirical story
Pejman Rohani & Aaron King — Host-pathogen dynamics: Multi-annual cycles, disease interference

1:30 PM to 2:30 PM: Strain Dynamics

Olivier Restif (discussion leader) — Current Bordetella Strains
Olivier Restif: Models — expanding the epidemiological models to incorporate strain dynamics

3:00 PM to 5:00 PM: Evolution

Andrew Preston & Duncan Maskell— Comparative genomics and trade offs between persistence and virulence
Olivier Restif — Co-evolution of Bordetellae: Effect of strain dynamics on co-evolution
Dan Wolfe — Non reciprocal cross immunity: B. pertussis and B. parapertussis in the same host populations by

Schedule: Saturday

9:00 AM to 10:00 AM: Host dynamics

Ottar Bjørnstad & Eric Harvill — Synthesis of previous day's talks and discussions taken from session syntheses
How host dynamics can shape evolution of strains
Additional perspectives

10:00 AM to 10:30 AM: Identification of topic areas for group discussions

Experimental, epidemiological, strain sampling/comparison, other scale/level of examination, etc.
Identify group members based on expertise.

11:00 AM - 12:30 PM: Focus in break-out group discussions

Identify pressing questions in each area.

1:30 PM - 3:00 PM: Discussion groups report back to entire group.

Whole group discussion, chaired by Duncan Maskell
Summary - Future research directions

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