Center for Infectious Disease Dynamics
CIDD brings together scientists in a range of complementary disciplines to innovate in infectious disease research.
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- Job opportunities
- Faculty Appointments in Infectious Disease: The Evolution & Dynamics of Pathogens We are seeking interactive, interdisciplinary candidates who are Mathematicians, Physicists, Statisticians, Climate Modelers or Biologists, to work across disciplines and identify novel insights and solutions to managing the disease burden. — Posted Jul 02, 2009
- Highlights from recent research
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Daily temperature fluctuations affect malaria transmission potential
Most climate-based malaria transmission models utilize mean monthly temperatures to explore the impact of climate on infection dynamics. According to CIDD researchers, this leads to an overestimation of malaria transmission in higher temperature areas and underestimation of transmission in lower temperature areas. Their studies show that daily temperature fluctuations greatly influence the incubation period of parasites in their vector, which alters malaria transmission potential.
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- Read paper on journal website : Understanding the link between malaria risk and climate, Proceedings of the National Academy of Sciences of the United States of America (2009)
- Go to a press release about this research
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Birth rates and vaccination affect the timing of rotavirus epidemics
Experts have been at a loss to explain the pattern of rotavirus epidemics in the U.S, in which seasonal activity begins in the southwest and ends in the northeast each year. Using epidemiological modeling, CIDD researchers have revealed that geographic differences in birth rate explain this apparent traveling wave. Their model also clarifies the impacts of vaccination and herd immunity.
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- Read paper on journal website : Demographic Variability, Vaccination, and the Spatiotemporal Dynamics of Rotavirus Epidemics, Science (2009)
- Go to a press release about this research
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Targeted insecticides could reduce malaria
Using insecticides indiscriminately can cause mosquitoes to built up a resistance to the insecticides creating a never ending race to engineer new insecticides. By changing the approach and creating insecticides that only target older mosquitoes the pressure to reproduce is reduced and the chances of building a resistance are greatly reduced.
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- Read paper on journal website : How to make evolution-proof insecticides for Malaria control, PLoS Biology (2009)
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Climate change and fungal disease in amphibians
Many amphibian extinctions in recent decades were apparently caused by a fungal disease. But what underlies increased disease incidence? Has climate change made it easier for the fungus to spread? Or has the fungus been introduced in more places independently of climate change? A new data analysis shows that neither theory explains observed amphibian population declines well. Instead, a mix of factors may be responsible
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- Read paper on journal website : Evaluating the links between climate, disease spread, and amphibian declines, PNAS (2008)
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Tropical reservoir for human influenza?
An analysis of more than 1300 complete influenza genomes shows different evolutionary patterns for two important viral subtypes (A/H1N1 and A/H3N2). Changes in diversity through time in northern and southern hemispheres suggest that for each of these subtypes, new strains arise from a reservoir in the tropics and move out to temperate regions.
- Read longer synopsis
- Read paper on journal website : The genomic and epidemiological dynamics of human influenza A virus, Nature (2008)
