Study systems include
Marek's disease of chickens
Myxomatosis in rabbits
Huijben et al. (2013). Aggressive chemotherapy and the selection of drug resistant pathogens. PLoS Pathogens
Barclay, V.C., Sim, D., Chan, B.H.K., Nell, L.A., Rabaa, M.A., Bell, A.S., Anders, R.F., Read, A.F. (2012). The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi. PLoS Biology 10: e1001368.
Read, A.F., Day, T., & Huijben, S. (2011) The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy. Proceedings of the National Academy of Science USA. 108: 10871-10877.
Read, A.F., Lynch, P.A. & Thomas, M.B. (2009) How to build an evolution-proof insecticide for malaria control. PLoS Biology. 7 (4). e1000058.
Read AF & Mackinnon MJ (2008) Pathogen evolution in a vaccinated world. pp. 139-152 in Stearns SC & Koella J, Evolution in Health and Disease, 2nd edition, Oxford University Press
Raberg L, Sim D & Read AF (2007) Disentangling genetic variation for resistance and tolerance to infectious diseases in animals. Science 318: 812-814
Wargo AR, Huijben S, de Roode JC, Shepard J & Read AF (2007) Competitive release and facilitation of drug resistant parasites following therapeutic chemotherapy in a rodent malaria model. Proceedings of the National Academy of Science USA 104: 19914-19919
Blanford S, Chan BHK, Jenkins N, Sim D, Turner RJ, Read AF & Thomas MB (2005) Fungal pathogen reduces potential for malaria transmission. Science 308: 1638-164
de Roode et al. (2005) Virulence and competitive ability in genetically diverse malaria infections. PNAS
My research focuses on the ecology and evolutionary genetics of pathogens. Questions of current interest include:
- Can we make evolution-proof drugs, vaccines and insecticides?
- Will vaccination and chemotherapy prompt the evolution of more virulent pathogens?
- Can entomopathogenic fungi be used to produce a cheap organic pesticide for sustainable malaria control?