Study systems include
Marek's disease of chickens
Myxomatosis in rabbits
Read, A.F., Baigent, S.J., Powers, C., Kgosana, L.B., Blackwell, L., Smith, L.P., Kennedy, D.A., Walkden-Brown, S.W., & Nair, V.K. (2015). Imperfect vaccination can enhance the transmission of highly virulent pathogens. PLoS Biology 13: e1002198.
Huijben et al. (2013). Aggressive chemotherapy and the selection of drug resistant pathogens. PLoS Pathogens 9:e1003578. PMC3771897.
Barclay, V.C., Sim, D., Chan, B.H.K., Nell, L.A., Rabaa, M.A., Bell, A.S., Anders, R.F. & Read, A.F. (2012). The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi. PLoS Biology 10: e1001368. PMC3409122.
Read, A.F., Day, T., & Huijben, S. (2011) The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy. Proceedings of the National Academy of Science USA. 108: 10871-10877. PMC3131826.
Read, A.F., Lynch, P.A. & Thomas, M.B. (2009) How to build an evolution-proof insecticide for malaria control. PLoS Biology. 7 (4). e1000058. PMC3279047
Read AF & Mackinnon MJ (2008) Pathogen evolution in a vaccinated world. pp. 139-152 in Stearns SC & Koella J, Evolution in Health and Disease, 2nd edition, Oxford University Press
Raberg L, Sim D & Read AF (2007) Disentangling genetic variation for resistance and tolerance to infectious diseases in animals. Science 318: 812-814
My research focuses on the ecology and evolutionary genetics of pathogens. Questions of current interest include:
- Can we make evolution-proof drugs, vaccines and insecticides?
- Will vaccination and chemotherapy prompt the evolution of more virulent pathogens?
- Can entomopathogenic fungi be used to produce a cheap organic pesticide for sustainable malaria control?