Ashutosh (Ash) K. Pathak
Study systems include
- Bordetella bronchiseptica, Graphidium strigosum and Trichostrongylus retortaeformis in rabbits
- Bordetella bronchiseptica in mice
Pathak AK, Pelensky C, Boag B, Cattadori IM. Immuno-epidemiology of chronic bacterial and helminth co-infections: Observations from the field and evidence from the laboratory. Int J Parasitol. 2012. In press.
Thakar J, Pathak AK, Murphy L, Albert R, Cattadori IM. Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth. PLoS Comput Biol. 2012, 8:e1002345.
Pathak AK, Biarnes MC, Murphy L, Cattadori IM. Snapshot of spatio-temporal cytokine responses to single and co-infections with helminths and bacteria. Results in Immunology. 2011 May. 1: 95-102.
Pathak AK, Creppage KE, Werner JR, Cattadori IM. Immune regulation of a chronic bacterial infection and consequences for pathogen transmission. BMC Microbiology. 2010 Aug 25;10:226.
Pathak AK, Boag B, Poss M, Harvill ET, Cattadori IM. Seasonal breeding drives the incidence of a chronic bacteria infection in a free-living herbivore population. Epidemiol Infect. 2011 Aug;139(8):1210-9.
Vinogradov E, King JD, Pathak AK, Harvill ET, Preston A. Antigenic variation among Bordetella; Bordetella bronchiseptica strain MO149 expresses a novel O chain that is poorly immunogenic. J Biol Chem. 2010 Aug 27;285(35):26869-77.
I am interested in the ecology and evolution of host-parasite interactions, generally at the level of the immune system.
I investigate these processes across multiple scales in two mutually dependent systems; laboratory and wild rabbit infections with the bacterium Bordetella bronchiseptica and 2 gastrointestinal nematodes Graphidium strigosum and Trichostrongylus retortaeformis. Broadly, questions I am interested in are:
Who infects whom, when and how?
What makes them infectious?
Finally, how can we intervene and what are the consequences?