Study systems include
Comparative microbial genomics and sequencing
Bordetella model of infection
Nicholson TL, Buboltz AM, Harvill ET and Brockmeier SL (2009) Microarray and functional analysis of growth-phase dependent gene regulation in Bordetella bronchiseptica. Infection and Immunity. In Press.
Buboltz AM, Nicholson TL, Weyrich LS and Harvill ET. (2009) Role of the Type Three Secretion System in a Hypervirulent Lineage of Bordetella bronchiseptica. Infection and Immunity. 77(9):3969-77.
Buboltz AM, Nicholson TL, Karanikas AT, Preston A and Harvill ET. (2009) Evidence of horizontal gene transfer of two antigenically distinct O antigens in Bordetella bronchiseptica. Infection and Immunity. 77(8):3249-57.
Wolfe DN, Buboltz AM and Harvill ET. (2009) Inefficient Toll-like receptor-4 stimulation enables Bordetella parapertussis to avoid host immunity. PLoS One. 4(1):e4280.
Buboltz AM, Nicholson TL, Parette MR, Hester SE, Parkhill J and Harvill ET. (2008) Replacement of Adenylate Cyclase Toxin in a lineage of Bordetella bronchiseptica. J. Bacteriol. 190(15):5502-11.
I am interested in the molecular evolution of virulence of bacterial pathogens, with emphasis on:
- Examining the bacterial molecular mechanisms behind why strains can cause asymptomatic and/or acute disease.
- Understanding how and why strains causing different levels of a disease phenotype arise and succeed.
- Determining if direct, or immune-mediated, competition occurs between strains and how bacterial factors affect this competition.