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Anne Buboltz
Study systems include
Bordetella
Comparative microbial genomics and sequencing
Transcriptomics
Bordetella model of infection
Bacterial genetics
Phylogenetics
Selected publications
Nicholson TL, Buboltz AM, Harvill ET and Brockmeier SL (2009) Microarray and functional analysis of growth-phase dependent gene regulation in Bordetella bronchiseptica. Infection and Immunity. In Press.
Buboltz AM, Nicholson TL, Weyrich LS and Harvill ET. (2009) Role of the Type Three Secretion System in a Hypervirulent Lineage of Bordetella bronchiseptica. Infection and Immunity. 77(9):3969-77.
Buboltz AM, Nicholson TL, Karanikas AT, Preston A and Harvill ET. (2009) Evidence of horizontal gene transfer of two antigenically distinct O antigens in Bordetella bronchiseptica. Infection and Immunity. 77(8):3249-57.
Wolfe DN, Buboltz AM and Harvill ET. (2009) Inefficient Toll-like receptor-4 stimulation enables Bordetella parapertussis to avoid host immunity. PLoS One. 4(1):e4280.
Buboltz AM, Nicholson TL, Parette MR, Hester SE, Parkhill J and Harvill ET. (2008) Replacement of Adenylate Cyclase Toxin in a lineage of Bordetella bronchiseptica. J. Bacteriol. 190(15):5502-11.
Research interests
I am interested in the molecular evolution of virulence of bacterial pathogens, with emphasis on:
- Examining the bacterial molecular mechanisms behind why strains can cause asymptomatic and/or acute disease.
- Understanding how and why strains causing different levels of a disease phenotype arise and succeed.
- Determining if direct, or immune-mediated, competition occurs between strains and how bacterial factors affect this competition.
