Study systems include
Zhang X, Hester SE, Kennett MJ, Karanikas AT, Bendor L, Place DE, Harvill ET. (2011) Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis. Infection and Immunity. Epub Oct 25.
Long GH, Karanikas AT, Harvill ET, Read AF, Hudson PJ. (2010) Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis. Proceedings of the Royal Society. Epub March 3.
Wolfe DN1, Karanikas AT1, Hester SE, Kennett MJ, Harvill ET. (2010) IL-10 induction by Bordetella parapertussis limits a protective IFN-gamma response. Journal of Immunology. 184(3)1392:1400.
Buboltz AM, Nicholson TL, Karanikas AT, Preston A, Harvill ET. (2009) Evidence for horizontal gene transfer of two antigenically distinct O antigens in Bordetella bronchiseptica. Infection and Immunity. 77(8): 3249-3257.
I am interested in studying the interactions between the three classical bordetellae and the host immune system. My particular interests include the following:
- Host responses induced by Bordetella infection and the immune components required for bacterial clearance. Specifically, I am interested in the role of Itk (IL-2 inducible T cell kinase) signaling in host immunity against B. pertussis and B. parapertussis. Additionally, I am investigating the importance of IL-1R signaling in B. bronchiseptica infection.
- Vaccine-induced immunity against B. pertussis and B. parapertussis.
- Characterization of a newly emerging pathogen, B. holmesii, as well as currently circulating B. pertussis strains.