Study systems include
Human and Avian metapneumoviruses
Padhi A, Moore AT, Bomberger BM, Foster JE, Pfeffer M, Gaines KP, O’Brien VA, Strickler SA, Johnson AE & Brown CR (2008) Phylogeographic structure and evolutionary history of two buggy creek virus lineages in the western great plains of North America. Journal of General Virology, in press.
Brown CR, Bomberger BM, Padhi A, Foster JE, Moore AT, Pfeffer M & Komar N (2008) Host and vector movement affects genetic diversity and spatial structure of Buggy Creek virus (Togaviridae). Molecular Ecology 17: 2164-2173
Padhi A & Verghese B (2008) Detecting molecular adaptation at individual codons in the glycoprotein gene of the geographically diversified infectious hematopoietic necrosis virus, a fish rhabdovirus. Virus Research 132: 229-236
Padhi A, Buchheim MA & Verghese B (2008) Dynamic evolutionary pattern of α2-macroglobulin in a model organism, the Zebrafish (Danio rerio). Molecular Immunology 45: 3312-3318
Padhi A & Verghese B (2008) Molecular diversity and evolution of myticin-C antimicrobial peptide variants in the Mediterranean mussel, Mytilus galloprovincialis. Peptides 29: 1094-1101
I am interested in understanding the forces that cause dynamic evolutionary patterns in different kinds of biological system. I use laboratory and computational approaches to address fundamental questions about evolutionary and population genetics of pathogens and their hosts.
- Understanding the importance of natural selection, recombination, gene flow, and drift in the evolution of pathogens.
- Population dynamics of pathogens using genomic approaches
- Host demographic structure using viral genes as markers