Laura Shackelton
Was a Postdoctoral Researcher in CIDD until 2008
Research while at CIDD
My research focused on the differences in the evolutionary genetics of large and small DNA viruses. Iinvestigated the rates and characteristics of nucleotide substitution in the small single-stranded DNA viruses, including:
- The nucleotide substitution rates and population dynamics of human B19 erythrovirus and the carnivore parvoviruses
- The recent emergence of canine parvovirus from feline panleukopenia virus
- The phylogenetic relationships and genome characteristics of autonomous and helper-dependent parvoviruses
- The long-term evolution of human JC virus
Study systems include
Parvoviruses
Publications include
Duffy S, Shackleton LA & Holmes EC (2008) Rates of evolutionary change in viruses: patterns and determinants. Nature Reviews Genetics 9, 267-276
McErlean P, Shackelton LA Lambert SB, Nissen MD, Sloots TP, Mackay IM (2007) Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis. J. Clin. Virol. 39: 67-75.
Shackelton LA Andrew Rambaut, Oliver G. Pybus and Edward C. Holmes (2006) JC Virus evolution and its association with human populations. J. Virol. 80: 9928-9933.
Shackelton LA & Holmes EC (2006) Phylogenetic evidence for the rapid evolution of human B19 erythrovirus. J. Virol. 80: 3666-3669.
Shackelton LA, Parrish CR, Truyen U & Holmes EC (2005) High rate of viral evolution associated with the emergence of carnivore parvovirus. PNAS 102: 379-384.
Shackelton LA & Holmes EC (2004) The evolution of large DNA viruses: combining genomic information of viruses and their hosts. Trends Microbiol. 12: 458-465.
people