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Craig E Cameron
Study systems include
Positive-strand RNA viruses: picornaviruses, flaviviruses and togaviruses
Selected publications
1. Arnold, J.J., Sharma, S.D., Feng, J.Y., Ray, A.S., Smidansky, E.D., Kireeva, M.L., Cho, A., Perry, J., Vela, J., Park, Y., Xu, Y., Tian, Y., Babusis, D., Barauskus, O., Peterson, B.R., Gnatt, A., Kashlev, M., Zhong, W. and Cameron, C.E. (2012). Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides. PLOS Pathogens. 8, e1003030.
2. Weeks, S.A., Lee, C.A., Zhao, Y., Smidansky, E.D., August, A., Arnold, J.J. and Cameron, C.E. (2012). A polymerase mechanism-based strategy for viral attenuation and vaccine development. J. Biol. Chem. 287, 31618-22.
3. Lodeiro, M.F., Uchida, A., Bestwick, M., Moustafa, I., Arnold, J.J., Shadel, G.S., and Cameron, C.E. (2012). Transcription from the second heavy-strand promoter of human mitochondrial DNA is repressed by transcription factor A in vitro. Proc. Natl. Acad. Sci. (USA) 109, 6513-8.
4. Graci, J.D., Gnädig, N.F., Galarraga, J.E., Castro C., Vignuzzi, M. and Cameron C.E. (2012). Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. J. Virol. 86, 2869-2873.
Professor and Eberly Chair in Biochemistry and Molecular Biology
Email: cec9@psu.edu
Phone: 814-863-8705 (office) 814-863-8703 (lab)
Office: 201 Althouse Laboratory
Research interests
My laboratory is interested in RNA polymerases and RNA-binding proteins required for viral replication, viral pathogenesis or mitochondrial function. Our current research objectives include the following:
- Function, dynamics and structure of viral RNA-dependent RNA polymerases (RdRp)
- Consequences and mechanisms of perturbed RdRp fidelity in viral pathogenesis
- Viral protein-lipid interactions in the biogenesis of viral replication organelles
- Hepatitis C virus persistence (in vitro and in vivo)
