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Daniel Elleder
Study systems include
- Feline immunodeficiency virus (FIV)
- Ungulate gammaretroviruses
Selected publications
Konig, R., Zhou, Y., Elleder, D., Diamond, T.L., et al. 2008. Global analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication. Cell, 135:49-60.
Reinišová, M., Šenigl, F., Yin, X., Plachý, J., Geryk, J., Elleder, D., Svoboda, J., Federspiel, M.J. and Hejnar, J. 2008. A single-amino-acid substitution in the TvbS1 receptors results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo. J. Virol., 82:2097-2105.
Elleder, D., Stepanets, V., Melder, D.C., Šenigl, F., Geryk, J., Pajer, P., Plachý, J., Hejnar, J., Svoboda, J. and Federspiel, M.J. 2005. The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily. J. Virol., 79:10408-10419.
Elleder, D., Melder, D.C., Trejbalová, K., Svoboda, J. and Federspiel, M.J. 2004. Two different molecular defects in the Tva receptor gene explain the resistance of two tva-r lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses. J. Virol., 78:13489-13500.
Elleder, D., Plachý, J., Hejnar, J., Geryk, J and Svoboda, J. 2004. Close linkage of genes encoding receptors for subgroups A and C of avian sarcoma/leucosis virus on chicken chromosome 28. Anim. Genet., 35:176-181.
Elleder, D., Pavlíček, A., Pačes, J. and Hejnar, J. 2002. Preferential integration of human immunodeficiency virus type 1 into genes, cytogenetic R bands and GC-rich DNA regions: insight from the human genome sequence. FEBS Letters, 517:285-286.
Research interests
We are using a unique model of lentivirus pathogenesis in mammalian host, namely coinfection of cats with two feline immunodeficiency viruses (FIV). Infection with the non-pathogenic FIV derived from wild cougars can protect from otherwise progressive immune decline and ultimately death caused by a virulent FIV strain. We are trying to dissect the particular host and viral components that contribute to the protection. Specifically we are following the adaptive and innate immune responses elicited by the non-pathogenic FIV, the role played by the cat antiviral gene cytidine deaminase, and the role of the virus infectivity factor (Vif).
I am also involved in a project that is aimed at characterization of novel gammaretroviruses in ungulates (mule deer). This originated from a metagenomic study that employed 454 sequencing of tissue samples of wild mule deer.
