Eric T. Harvill
Study systems include
Bordetella: closely-related subspecies differing in virulence and gene expression (B.pertussis, B.parapertussis and B.bronchiseptica)
Laboratory in-vitro and in-vivo studies (using a mouse model)
Hester SE, Goodfield LL, Park J, Feaga JA, Ivanov Y, Bendor L, Taylor DL, Harvill ET. Host specificity of ovine Bordetella parapertussis and the role of complement. PLoS ONE; 2015 Jul 9;10(7):e0130964. doi: 10.1371/journal.pone.0130964. eCollection 2015.
Register KB, Ivanov YV, Harvill ET, Brinkac L, Kim M, Losada L. (2015) Draft genome sequences of six Bordetella hinzii isoletes acquired from avian and mammalian hosts. Genome Announcements; 3(2). DOI:10.1128/genomeA.00081-1.
Register KB, Ivanov YV, Jacobs N, Meyer JA, Goodfield LA, Muse SJ, Smallridge WE, Brinkac L, Kim M, Sanka R, Harvill ET, Losada L. (2015) Draft genome sequences of 53 genetically distinct isolates of Bordetella bronchiseptica representing 11 terrestrial and aquatic hosts. Genome Announcements; 3(2). DOI:10.1128/genomeA.00152-15.
Malys T, Linz B, Ivanov Y, Shabbir MZ, Rabbani M, Ahmad H, Shabbir MAB, Raygoza Garay JA, Mwangi MM, Yaqub T, Ahmad A, Harvill ET. (2014) The microbiome of the lower respiratory tract of healthy and diseased chickens from Pakistan. PLoS ONE.
Gorgojo J, Harvill ET, Rodriguez ME. (2014) Bordetella parapertussis survives inside human pacrophages in lipid raft enriched phagosomes. Infection and Immunity; 2014 Dec;82(12):5175-84. doi: 10.1128/IAI.02553-14. Epub 2014 Sep 29.
Place DE, Muse SJ, Kirimanjeswara GS, Harvill ET. (2014) Caspase-1-independent interleukin-1β is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity. (2014) PLoS ONE; 9(9):e107188. DOI:10.1371/journal.pone.0107188.
Harvill ET, Goodfiel LL, Ivanov Y, Smalldrige WE, Meyer JA, Cassiday PK, Tondella ML, Brinkac L,Sanka R, Kim N, Losada L. (2014) Genome sequences of nine Bordetella holmesii strains isolated in the United States. Genome Announcements; 2(3). DOI:10.1128/genomeA.00438-1.
Hewlett EK, Burns DK, Cotter PA, Harvill ET, Merkel TJ, Quinn CO, Stibitz ES. (2014) Pertussis pathogenesis - what we know and what we don't know. The Journal of Infectious Diseases; 209(7):982-5. DOI:10.1093/infdis/jit639.
Bart MJ, Harris SR, Advani A, Arakawa Y, Bottero D, Bouchez V, Cassiday PK, Chiang C-S, Dalby T, Fry NK, Gaillard ME, van Gent M, Guiso N, Hallander HO, Harvill ET, He Q, van der Heide H, Keuvelman K, Hozbor D, Kamachi K, Karataev GI, Lan R, Lutylska A, Maharjan RP, Mertsola J, Miyamura T, Octavia S, Preston A, Quail MA, Sintchenko V, Stefanelli P, Tondella ML, Tsang RSW, Xu Y, Yao S-M, Zhang S, Parhill J, Mooi F. (2014) Global population structure and volution of Bordetella pertussis and their relationship with vaccination. mBio; 5(2). DOI:10.1128/mBio.01074-14.
Rolin O, Muse SJ, Chetan S, Shokrollah E, Gerdts V, Hittle LE, Ernst RK, Harvill ET, Preston A. (2014) Enzymatic modification of lipid A by ArnT protects Bordetella bronchiseptica against cationic peptides and is required for transmission. Infection and immunity; 82(2):491-9. DOI:10.1128/IAI.01260-12.
Smallridge WE, Rolin OY, Jabocs NT, Harvill ET. (2014) Different effects of whole-cell and acellular vaccines on Bordetella transmission. The Journal of Infectious Disease; 2014 Jun 15;209(12):1981-8. doi: 10.1093/infdis/jiu030. Epub 2014 Jan 16.
Rolin O, Smallridge W, Henry M, Goodfield L, Place D, Harvill ET. (2014) Toll-like receptor 4 limits transmission of Bordetella bronchiseptica. PLoS ONE; 9(1):e85229. DOI:10.1371/journal.pone.0085229.
Weyrick LS, Feaga HA, Park J, Muse SJ, Chetan YS, Rolin OY, Young SE, Harvil ET. (2013) Resident microbiota affect Bordetella pertussis infectious dose and host specificity. The Journal of Infectious Diseases; 2014 Mar;209(6):913-21. doi: 10.1093/infdis/jit597. Epub 2013 Nov 13.
Harvill ET, Goodfiel, LL, Ivanov Y, Meyer JA, Newth C, Cassiday P, Tondella MK, Liao P, Zimmermann J, Meert K, Wessel D, Berger J, Dean JM, Holubkov R, Burr J, Liu T, Brinkac L, Kim M, Losada L. (2013) Genome sequences of 28 Bordetella pertussis U.S. outbreak strains dating from 2010 to 2012. Genome Announcements; 1(6). DOI:10.1128/genomeA.01075-13.
Hester SE, Park J, Goodfield LL, Feaga HA, Preston A, Harvill ET. (2013) Horizontally acquired divergent O-antigen contributes to escape from cross-immunity in the classical bordetellae. BMC Evolutionary Biology; 13(1):209. DOI:10.1186/1471-2148-13-209.
Pinkerton M, Chinchilli V, Banta E, Craig T, August A, Bascom R, Cantorna M, Harvill ET, Ishmael FT. (2013) Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease and healthy adults. The Journal of allergy and clinical immunology; 132(1). DOI:10.1016/j.jaci.2013.03.006.
Berger JT, Carcillo JA, Shanley TP, Wessel DL, Clark A, Holubkov R, Meert KL, Newth CJL, Berg RA, Heidemann S, Pollac M, Dalton H, Harvill ET, Karanikas A, Liu T, Burr JS, Doctor A, Dean JM, Jenkins TL, Nicholson CE (2013) Critical pertussis illness in children: a multicenter prospective cohort study. Pediatric Critical Care Medicine; DOI:10.1097/PCC.0b013e31828a70fe.
Lass S, Hudson PJ, Thakar J, Saric J, Harvill ET, Albert R, Perkins SE. Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth. (2013) Journal of The Royal Society Interface; 10(80):20120588. DOI:10.1098/rsif.2012.0588.
Harvill ET. (2013) “Cultivating Our Frienemies: Viewing Immunity As Microbiome Management” mBio. 2013 Mar 26;4(2).
Weyrich SL, Feaga HA, Park J, Muse SJ, Safi CY, Rolin OY, Young SE, Harvill ET(2013) “Resident Microbiota Affect Bordetella pertussis Infectious Dose and Host Specificity” Journal of Infectious Diseases, accepted September 23, 2013.
Hester SE, Park J, Goodfield LL, Feaga HA, Preston A and Harvill ET (2013) “Horizontally Acquired Divergent O-antigen Contributes to Escape from Cross-Immunity in the Classical Bordetellae” BMC Evolutionary Biology, in press.
Lass S, Hudson PJ, Thakar J, Saric J, Harvill ET, Albert R, Perkins SE. (2013) “Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth”. J R Soc Interface. 2012 Dec 19;10(80):20120588.
Weyrich LS, Harvill ET (2013) “Teaching Ethical Aptitude to Graduate Student Researchers” Accountability in Research, 2013;20(1):5-12.
Park J, Zhang Y, Buboltz AM, Zhang X, Schuster SC, Ahuja U, Liu M, Miller JF, Sebaihia M, Bentley SD, Parkhill J, Harvill ET. (2012) Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens. BMC Genomics. 13(1):545.
Weyrich LS, Rolin OY, Muse SJ, Park J, Spidale N, Kennett MJ, Hester SE, Chen C, Dudley EG, and Harvill ET. (2012) “A Type VI Secretion System Encoding Locus is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo” PLoS ONE, 2012;7(10):e45892.
Gorgojo J, Lamberti Y, Valdez H, Harvill ET, Rodríguez ME. (2012) “Bordetella parapertussis survives the innate interaction with human neutrophils by impairing bactericidal trafficking inside the cell through a lipid raft-dependent mechanism mediated by the lipopolysaccharide O antigen.” Infect Immun. 2012 Oct 1.
Ahuja U, Liu M, Tomida S, Park J, Souda P, Whitelegge J, Li H, Harvill ET, Parkhill J, Miller JF. (2012) “Phenotypic and Genomic Analysis of Hypervirulent Human-associated Bordetella bronchiseptica.” BMC Microbiol. 2012 Aug 6;12:167.
Zhang X, Weyrich LS, Lavine JS, Karanikas AT, Harvill ET. (2012)“Lack of Cross-protection against Bordetella holmesii after Pertussis Vaccination.” Emerg Infect Dis. 2012 Nov;18(11):1771-9.
Hester SE, Lui M, Nicholson T, Nowacki D, and Harvill ET, (2012)“Identification of a CO2 responsive regulon in Bordetella” PLoS ONE, 2012;7(10):e47635.
Barchinger SE, Zhang X, Hester SE, Rodriguez ME, Harvill ET, Ades SE. (2012) “sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice.” BMC Microbiol. 2012 Aug 16;12(1):179.
I investigate how host and pathogen characteristics and host dynamics affect the spread of respiratory infection within individuals and host populations. My group has four main research areas:
- Effects of bacterial virulence factors on infection pathology and immune response to infection within a host
- How bacterial virulence factors such as toxins affect the dynamics of transmission between hosts (e.g. by lengthening infectious period)
Host immune functions
- Mechanisms of immune-mediated bacterial clearance: how they differ between organs of the respiratory tract
Comparing genomes of closely-related pathogens to investigate important questions such as:
- Which bacterial factors determine host specificity
- How animal pathogens adapt to infect humans
- What determines the severity of pathology
- How bacteria cause persistent infections that last for the life of the host
- Emergence of human pathogens from commensals of agricultural and companion animals
- The transmission and dynamics of disease within populations
For more about Eric T. Harvill, see:
- Bacterial Pathogenesis