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Eric Harvill
Study systems include
Bordetella: closely-related subspecies differing in virulence and gene expression (B.pertussis, B.parapertussis and B.bronchiseptica)
Laboratory in-vitro and in-vivo studies (using a mouse model)
Selected publications
Pathak, A. K., Boag, B., Poss, M., Harvill, E. T., & Cattadori, I. M. (2011). Seasonal breeding drives the incidence of a chronic bacterial infection in a free-living herbivore population. Epidemiology and Infection, 139(8), 1210-1219.
Zhang X, Goel T, Goodfield LL, Muse SJ, Harvill ET. (2011) Decreased Leukocyte Accumulation and Delayed Bordetella pertussis Clearance in IL-6-/- Mice. Journal of Immunology Apr 15;186(8):4895-904. Epub 2011 Mar 11
Long GH, Sinha D, Read AF, Pritt S, Kline B, Harvill ET, Hudson PJ, Bjørnstad ON. (2011) Identifying the age cohort responsible for transmission in a natural outbreak of Bordetella bronchiseptica. PLoS Pathogens 2010 Dec 16;6(12):e1001224.
Wolfe DN, Karanikas AT, Hester SE, Kennett MJ, Harvill ET. (2010) IL-10 Induction by Bordetella parapertussis Limits a Protective IFN-{gamma} Response. Journal of Immunology
Zhang X, Hester SE, Kennett MJ, Karanikas AT, Bendor L, Place DE, Harvill ET. (2010) IL-1R signaling is required to overcome the effects of pertussis toxin and for efficient infection or vaccination induced immunity against Bordetella pertussis. Infection and Immunity Oct 25.
Long GH, Karanikas AT, Harvill ET, Read AF, Hudson PJ (2010) Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis. Proc Biol Sci. 2010 Jul 7;277(1690):2017-25. Epub 2010 Mar 3.
Lavine J, Broutin H, Harvill ET, Bjørnstad ON. (2010) Imperfect vaccine-induced immunity and whooping cough transmission to infants. Vaccine. 2010 Dec 10;29(1):11-6. Epub 2010 Oct 27.
Pathak AK, Boag B, Poss M, Harvill ET, Cattadori IM.(2010) Seasonal breeding drives the incidence of a chronic bacterial infection in a free-living herbivore population. Epidemiol Infect. 2010 Oct 14:1-10.
Vinogradov E, King JD, Pathak AK, Harvill ET, Preston A. (2010) Antigenic Variation among Bordetella: Bordetella bronchiseptica strain MO149 expresses a novel o chain that is poorly immunogenic. J Biol Chem. 2010 Aug 27;285(35):26869-77. Epub 2010 Jun 30.
Lamberti YA, Hayes JA, Perez Vidakovics ML, Harvill ET, Rodriguez ME.(2010) Intracellular trafficking of Bordetella pertussis in human macrophages. Infection and Immunity 2010 Mar;78(3):907-13. Epub 2010 Jan 11
Associate Professor of Microbiology and Infectious Disease
Email: harvill@psu.edu
Phone: 814-863-8522
Office: 124 Agricultural Sciences and Industries (ASI) Building
Research interests
I investigate how host and pathogen characteristics and host dynamics affect the spread of respiratory infection within individuals and host populations. My group has four main research areas:
Virulence factors
- Effects of bacterial virulence factors on infection pathology and immune response to infection within a host
- How bacterial virulence factors such as toxins affect the dynamics of transmission between hosts (e.g. by lengthening infectious period)
Host immune functions
- Mechanisms of immune-mediated bacterial clearance: how they differ between organs of the respiratory tract
Genomics
Comparing genomes of closely-related pathogens to investigate important questions such as:
- Which bacterial factors determine host specificity
- How animal pathogens adapt to infect humans
- What determines the severity of pathology
- How bacteria cause persistent infections that last for the life of the host
Phylodynamics
- Emergence of human pathogens from commensals of agricultural and companion animals
The transmission and dynamics of disease within populations
