Study systems include
Bordetella: closely-related subspecies differing in virulence and gene expression (B.pertussis, B.parapertussis and B.bronchiseptica)
Laboratory in-vitro and in-vivo studies (using a mouse model)
Harvill ET. (2013) “Cultivating Our Frienemies: Viewing Immunity As Microbiome Management” MBio. 2013 Mar 26;4(2).
Lass S, Hudson PJ, Thakar J, Saric J, Harvill ET, Albert R, Perkins SE. (2013) “Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth”. J R Soc Interface. 2012 Dec 19;10(80):20120588.
Weyrich LS, Harvill ET (2013) “Teaching Ethical Aptitude to Graduate Student Researchers” Accountability in Research, 2013;20(1):5-12.
Park J, Zhang Y, Buboltz AM, Zhang X, Schuster SC, Ahuja U, Liu M, Miller JF, Sebaihia M, Bentley SD, Parkhill J, Harvill ET. (2012) Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens. BMC Genomics. 13(1):545.
Weyrich LS, Rolin OY, Muse SJ, Park J, Spidale N, Kennett MJ, Hester SE, Chen C, Dudley EG, and Harvill ET, (2012) “A Type VI Secretion System Encoding Locus is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo” PLoS ONE, 2012;7(10):e45892.
Gorgojo J, Lamberti Y, Valdez H, Harvill ET, Rodríguez ME. (2012) “Bordetella parapertussis survives the innate interaction with human neutrophils by impairing bactericidal trafficking inside the cell through a lipid raft-dependent mechanism mediated by the lipopolysaccharide O antigen.” Infect Immun. 2012 Oct 1.
Ahuja U, Liu M, Tomida S, Park J, Souda P, Whitelegge J, Li H, Harvill ET, Parkhill J, Miller JF. (2012) “Phenotypic and Genomic Analysis of Hypervirulent Human-associated Bordetella bronchiseptica.” BMC Microbiol. 2012 Aug 6;12:167.
Zhang X, Weyrich LS, Lavine JS, Karanikas AT, Harvill ET. (2012)“Lack of Cross-protection against Bordetella holmesii after Pertussis Vaccination.” Emerg Infect Dis. 2012 Nov;18(11):1771-9.
Hester SE, Lui M, Nicholson T, Nowacki D, and Harvill ET, (2012)“Identification of a CO2 responsive regulon in Bordetella” PLoS ONE, 2012;7(10):e47635.
Barchinger SE, Zhang X, Hester SE, Rodriguez ME, Harvill ET, Ades SE. (2012) “sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice.” BMC Microbiol. 2012 Aug 16;12(1):179.
I investigate how host and pathogen characteristics and host dynamics affect the spread of respiratory infection within individuals and host populations. My group has four main research areas:
- Effects of bacterial virulence factors on infection pathology and immune response to infection within a host
- How bacterial virulence factors such as toxins affect the dynamics of transmission between hosts (e.g. by lengthening infectious period)
Host immune functions
- Mechanisms of immune-mediated bacterial clearance: how they differ between organs of the respiratory tract
Comparing genomes of closely-related pathogens to investigate important questions such as:
- Which bacterial factors determine host specificity
- How animal pathogens adapt to infect humans
- What determines the severity of pathology
- How bacteria cause persistent infections that last for the life of the host
- Emergence of human pathogens from commensals of agricultural and companion animals
- The transmission and dynamics of disease within populations
For more about Eric Harvill, see:
- Bacterial Pathogenesis