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Juilee Thakar
Study systems include
Bordetella bronchiseptica and B. pertussis
Selected publications
Thakar J, Pilione M, Kirimanjeswara G, Harvill ET & Albert R (2007) Modeling systems-level regulation of host immune responses. PLoS Computational Biology 3(6): e109.
Christensen C, Thakar J & Albert R (2007) Systems-level insights into cellular regulation: inferring, analyzing and modeling intercellular networks. IET Systems Biology 1: 61-77.
Thakar J, Schleinkofer K & Dandekar T (2006) RIP death domain structural interactions implicated in TNF-mediated proliferation and survival. Proteins 63: 413-42.
Postdoctoral Researcher
Email: jthakar@phys.psu.edu
Phone: 814-865-4972
Office: 104 Davey Laboratory
Research interests
Currently I am studying system-level host-pathogen interactions and dynamics that arise during the pathogenesis of infectious disease. I primarily use powerful methods of network theory and dynamic modeling. I also use phylogenetic, sequence analysis and structural modeling tools.
Experimental and clinical observations parameterize the network of host immune components and pathogen virulence factors catalyzed by pathogen invasion. Dynamic modeling of the network enables us to:
- Infer how immune components interact with virulence factors
- Analyze and predict time course of immune responses
- Analyze the role of immune components
- Study the dynamics arising from co-infections and secondary infections
