Study systems include
Endogenous retroviruses in cervids and humans
Prabhakara, S, R. Malhotra, R Acharya, M Poss. 2013. Mutant Bin: Unsupervised Haplotype Estimation of Viral Population Diversity Without Reference Genome. 2013. J Comp Bio. in press
Antonovics, Janis, Mike Boots, Dieter Ebert, Britt Koskella, Mary Poss, Ben Sadd. The origin of specificity by means of natural selection: evolved and non-host resistance in host-pathogen systems. 2013. Evolution. 67(1):1-9
Elleder, D, O Kim, A Pahi, J Banker, I Simeonov, S Schuster, N Wittekindt, S Motameny, M Poss. (2012). Polymorphic integrations of an endogenous gammaretrovirus in the mule deer genome. J. Virol 86:2787.
Poss, M. 2011. Virus Dynamics and Evolution: Bridging Scales and Disciplines. Viruses 2011, 3, 1432-1438.
Li, L, A Padhi, S Ranjeva, S Donaldson, B Warf, J Mugamba, D Johnson, Z Opio, B Jayarao, V Kapur, M Poss, S Schiff. 2011. Association of Bacteria with Hydrocephalus in Ugandan Infants. J Neurosurg Pediatrics.7:73-87.
Wittekindt, N., Padhi A., Schuster, S., Qi, J., Zhao, F., Tomsho, L., Kasson, L., Packard, M., Cross, P., & Poss, M., (2010). Nodeomics: meta-transcriptomic exploration of a vertebrate lymph node microbiome. PLoS One 5(10): e13432. doi:10.1371/journal.pone.0013432.
Viruses as markers of host population dynamics
We integrate empirical, statistical, and computational approaches to investigate how endogenous virus reflect host population demographics. This research has application to species conservation and to the ecology of infections in natural host populations.
Endogenous retroviruses, genome evolution, and disease
We investigate how host genomes evolve in the presence of recently acquired, transcriptionally active, endogenous retroviruses and how these viruses evolve in the new environment of the host genome. We are also studying the role of endogenous retroviruses in genome structural variation and human cancer.
Within host virus dynamics
Two viruses can be better than one. We are using high throughput sequencing approaches to study the molecular mechanisms of disease attenuation that occurs during coinfection with virulent and apathogenic feline lentiviruses.
Neonatal Sepsis and hydrocephalus
Infectious disease contributes to the high rate of infant mortality in developing countries and can have debilitating sequelae including hydrocephalus in survivors. We are employing metagenomic and metatranscriptomic methods in an international collaborative effort to study the neonatal septisome and prevent infant infectious diseases and subsequent neurological complications.