Study systems include
Endogenous retroviruses in cervids and humans
Prabhakara, S, R. Malhotra, R Acharya, M Poss. 2013. Mutant Bin: Unsupervised Haplotype Estimation of Viral Population Diversity Without Reference Genome. J Comp Bio. 20(6):453-63.
Chong, YL, T Tsan-Yuk Lam, O Kim1, H Lu, P Dunn, and M Poss. 2013. Successful Establishment and Global Dispersal of Genotype VI Avian Paramyxovirus Serotype 1 after Cross Species Transmission. Inf Gen Evo 2013. 17:260-68
Kamath, P, D Elleder, L Bao, P Cross, M Poss. 2013. The population history of endogenous retroviral elements in mule deer (Odocoileus hemionus). 2013. J Heredity. doi:10.1093/jhered/est088
Kiwanuka J, J Bazira, J Mwanga, D Tumusiime, E Nyesigire, N Lwanga, B C Warf, M Poss, V Kapur, S J Schiff. 2013 The Microbial Spectrum of Neonatal Sepsis in Uganda: Recovery of Culturable Bacteria in Mother-Infant Pairs. Plos One. DOI: 10.1371/journal.pone.0072775
Malhotra, R, S Prabhakara, M Poss, R Acharya. 2013. Estimating Viral Haplotypes in a Population Using k-mer Counting. PRIB 2013. 265-276
Malhotra,R S Prabhakara, M Poss, R Acharya. 2013. Estimating Viral Haplotypes in a Population Using k-mer Counting. In Pattern Recognition in Bioinformatics, p 265-276. Springer Press.
Chong YL, Kim O, Poss M. Lineage diversification of pigeon paramyxovirus effect re-emergence potential in chickens. Virology. 2014 Aug;462-463:309-17. doi: 10.1016/j.virol.2014.06.007. Epub 2014 Jul 8. PubMed PMID: 25010480.
Bao, L, D Elleder, R Malhotra, M DeGiorgio, TMaravegias, L Horvath, L Carrel, C Gillin, T Hron, H Fábryová, D Hunter, M Poss. 2014. Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism. Computation2:221 (Special edition on Genomes and Evolution)
Liu Y, Chiaromonte F, Ross H, Malhotra R, Elleder D, Poss M. Error correction and statistical analyses for intra-host comparisons of feline immunodeficiency virus diversity from high-throughput sequencing data. BMC Bioinformatics. 2015 Jun 30;16:202. doi: 10.1186/s12859-015-0607-z. PubMed PMID: 26123018; PubMed Central PMCID: PMC4486422.
Kamath, P, D Elleder, L Bao, P Cross, M Poss. 2013. The population history of endogenous retroviral elements in mule deer (Odocoileus hemionus). J Hereditiy. In press.
Chong, Y L, T Lam, O Kim, H Lu, P Dunn, M Poss. 2013. Successful establishment and global dispersal of genotype VI Avian paramyxovisur seotype 1 after cross species transmission. Inf Gen Evo. 17: 260-68
Prabhakara, S, R. Malhotra, R Acharya, M Poss. 2013. Mutant Bin: Unsupervised Haplotype Estimation of Viral Population Diversity Without Reference Genome. 2013. J Comp Bio. 20:453-63
Antonovics, J, M Boots, D Ebert, B Koskella, M Poss, B Sadd. 2013The origin of specificity by means of natural selection: evolved and non-host resistance in host-pathogen systems. . Evolution. 67(1):1-9
Elleder, D, O Kim, A Pahi, J Banker, I Simeonov, S Schuster, N Wittekindt, S Motameny, M Poss. (2012). Polymorphic integrations of an endogenous gammaretrovirus in the mule deer genome. J. Virol 86:2787.
Poss, M. 2011. Virus Dynamics and Evolution: Bridging Scales and Disciplines. Viruses 2011, 3, 1432-1438.
Li, L, A Padhi, S Ranjeva, S Donaldson, B Warf, J Mugamba, D Johnson, Z Opio, B Jayarao, V Kapur, M Poss, S Schiff. 2011. Association of Bacteria with Hydrocephalus in Ugandan Infants. J Neurosurg Pediatrics.7:73-87.
Endogenous retroviruses, genome evolution, and cancer
We investigate how host genomes evolve in the presence of recently acquired, transcriptionally active, endogenous retroviruses and how these viruses evolve in the new environment of the host genome. We are also studying the role of endogenous retroviruses in genome structural variation and human cancer.
Within host virus dynamics
Two viruses can be better than one. We are using combined statistical and empirical approaches to study the molecular mechanisms of disease attenuation that occurs during coinfection with virulent and apathogenic feline lentiviruses.
Neonatal Sepsis and hydrocephalus
Infectious disease contributes to the high rate of infant mortality in developing countries and can have debilitating sequelae including hydrocephalus in survivors. We are employing metagenomic and metatranscriptomic methods in an international collaborative effort to study the neonatal septisome and prevent infant infectious diseases and subsequent neurological complications.