Study systems include
Barclay, V.C (In press) Variation in host resistance could limit the spread of more broadly virulent pathogens. Virulence
Barclay, V.C., Smith, R.A., Findeis, J.L. (2012). Surveillance considerations for malaria elimination. Malaria Journal 11:304
Barclay, V.C., Sim, D., Chan, B.H.K., Nell, L.A., Rabaa, M.A., Bell, A.S., Anders, R.F., Read, A.F. (2012). The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi. PLoS Biology 10: e1001368.
Metcalf, C.J.E., Graham, A.L., Huijben, S., Barclay, V.C., Long, G.H., Grenfell, B.T., Read, A.F., & Bjornstad, O.N (2011). Partitioning and quantifying regulatory mechanisms acting on within host malaria using the effective propagation number. Science 333, 984-988
Smith, R.A., Barclay, V.C and Findeis, J.L. (2011). Investigating preferences for mosquito control technologies in Mozambique with latent class analysis. Malaria Journal 10, 200
Barclay VC, Chan BHK, Anders RF and Read AF (2008) Mixed allele malaria vaccines: Host protection and within-host selection. Vaccine 26, 6099-6107.
Barclay VC, Raberg L, Chan BHK, Brown S, Gray D and Read AF (2008) CD4+ T cells do not mediate within host competition between genetically diverse malaria parasites. Proc R Soc 275, 1171-1179.
Mideo N, Barclay VC, Chan BHK, Savill NJ, Read AF, Day T (2008) Understanding and predicting strain-specific patterns of pathogenesis in the rodent malaria, Plasmodium chabaudi. Am Nat 172, 214-238.
Measuring contact rates, mixing patterns and influenza transmission in schools
The importance of different routes on influenza transmission remain poorly understood. At least three modes are possible, including droplet transmission (coughing, sneezing), airborne transmission (fine aerosolized viral particles), and contact transmission (touch). Schools are thought to plat a major role in the spread of influenza, but little is known on how influenza spreads through such communities, severely hampering our ability to control influenza outbreaks.
Our aim with this study is to get a very detailed picture - for the first time - on exactly how influenza spreads in a high school using the following methods:
- Wireless sensor motes: to monitor close proximity interactions (CPI) of individuals in a high school community
- Short on-line contact surveys: to measure the error in subjective (survey) versus objective (mote) methods in collecting contact data
- Disease surveillance: by collecting nose-throat samples from individuals experiencing influenza-like illness (ILI) we will diagnosis influenza using RT-PCR. Positive samples will then be full genome sequenced.