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Center for Infectious Disease Dynamics

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Two CIDD members among 16 faculty PSU just named as Distinguished Professors. Reka Albert, Professor of Physics and Biology, and Eric Harvill, Professor of Microbiology and Infectious Disease, are among the 16 faculty members that the Penn State Office of the Vice Provost for Academic Affairs just names as Distinguished Professors.
Battling drug-resistant pathogens Biologist Andrew Read argues for new treatment strategies in race against rapidly evolving 'bugs.'
Doctors Without Borders nurse brings her experience to Penn State MOOC Doctors Without Borders nurse brings her experience to Penn State MOOC The 2014 Epidemics MOOC brings together a worldwide audience to discuss the ongoing Ebola outbreak.
Job Opportunities
Ebola Programmer Analyst — Posted Apr 09, 2015
Postdoctoral Scholar - Rasgon Lab — Posted Mar 16, 2015
Postdoctoral Scholar - Rasgon Lab — Posted Mar 16, 2015
Postdoctoral Research Associate Department of Biology, Georgetown University, Washington DC, USA — Posted Feb 06, 2015
Postdoctoral Scholar: Disease transmission in societies — Posted Dec 03, 2014
Postdoctoral Position in Bacterial Pathogenesis, Host and Microbiota — Posted Nov 26, 2014
Postdoctoral Researcher - Adaptive Management of Foot-and-Mouth Disease — Posted Oct 06, 2014
Postdoctoral Scholar in Molecular Parasitology — Posted Mar 16, 2015
Highlights from recent research
Cytotoxic T lymphocytes modulate outcomes for patients receiving antiretroviral therapy for HIV Cytotoxic T lymphocytes modulate outcomes for patients receiving antiretroviral therapy for HIV Some patients are able to control HIV infections even after cessation of antiretroviral therapies, but the mechanisms allowing for this post-therapeutic control remain unclear. In a recent paper published in PNAS, CIDD researcher Jessica Conway and Alan Perelson from the Los Alamos National Laboratory explore the mechanisms that allow for post-treatment HIV control. The team shows that antiretroviral treatment outcomes may depend on a balance between the size of the reservoir of latently HIV-infected cells and how effectively the patient’s cytotoxic T lymphocytes (CTLs) control emerging HIV infection. By varying CTL efficacy and size of the latent HIV reservoir, their model reproduced the full range of observed post-infection HIV outcomes: post-treatment control, post-treatment viral rebound and re-establishment of infection, and natural pre-treatment control by patients known as ‘elite controllers’.
A humanized mouse model for Plasmodium vivax liver stage A humanized mouse model for Plasmodium vivax liver stage Recent work by CIDD researcher Scott Lindner and colleagues has demonstrated a successful new model system for studying a species of human malaria parasites that previously evaded researchers’ attempts to study the parasites in vivo: Plasmodium vivax. Vivax malaria has historically been less studied than malaria caused by another human malaria parasite, P. falciparum, despite P. vivax’s longer persistence and higher prevalence in Asia and South America. The successful new humanized mouse model developed by Lindner and colleagues should help to shift attention to increase research on drug treatments and liver stage development of this important parasite. Excitingly, this model also supports investigations of an elusive dormant form of the parasite, called a hypnozoite, that causes relapses months or years after the primary infection occurs. Now that we can study this stage of the parasite, we can begin to understand it. The development of the model was published in a recent edition of Cell Host & Microbe.
Ebola now, measles next? Ebola now, measles next? The disruption of routine healthcare measures in a time of epidemic crisis can lead to future epidemics of vaccine-preventable diseases. CIDD researcher Matt Ferrari and colleagues explore consequences of the Ebola virus disease beyond the high death toll from the virus itself. Published in Science, the work draws attention to the impinging threat of future epidemics from diseases whose prevention has been sidelined in crisis.
Targeting antibiotic stewardship programs: ‘Stewards’, ‘stockers’, and ‘demanders’ Targeting antibiotic stewardship programs: ‘Stewards’, ‘stockers’, and ‘demanders’ Using a novel, person-centered approach to identify drivers of antibiotic stewardship behaviors, CIDD researcher Rachel Smith and colleagues have been able to stratify the U.S. public into groups exhibiting similar ideology and behaviors. Identifying these target groups is an important step toward more effective stewardship campaigns.
Ecological dynamics of emerging bat virus spillover As the 2014 Ebola outbreak gradually winds down, the quest for animal reservoirs that could produce future outbreaks continues to intensify, with bat species attracting particular attention. Bats have received notoriety as reservoir hosts for many other emerging viruses, including SARS, Lyssaviruses, Nipah, and Hendra viuses. However, despite bats' potential roles as reservoir hosts and their widespread geographic range and high densities, pathogen spillover events remain relatively rare. Recent work published by CIDD researcher Raina Plowright and collaborators including CIDD member Peter Hudson, delineates the factors that align to generate a pathogen spillover event from bats into new host species.
» More Highlights from recent research
Millennium Science Complex

Millennium Science Complex as viewed from Pollock Field.

Many CIDD faculty and their research groups have re-located to Penn State’s new Millennium Science Complex. This is a state-of-the art research facility which will become the gateway for interdisciplinary research between the Life Sciences and the Material Sciences’ faculty and students.

Find out more about the building.

From proteins to pandemics

CIDD brings together scientists in a range of complementary disciplines to innovate in infectious disease research.

More about CIDD

Upcoming events

CIDD seminars are publicized on the Huck Institutes website

Monday discussions are held every Monday at 12pm in W-203 Millennium Science Complex

 
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