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Center for Infectious Disease Dynamics

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Two CIDD members among 16 faculty PSU just named as Distinguished Professors. Reka Albert, Professor of Physics and Biology, and Eric Harvill, Professor of Microbiology and Infectious Disease, are among the 16 faculty members that the Penn State Office of the Vice Provost for Academic Affairs just names as Distinguished Professors.
Battling drug-resistant pathogens Biologist Andrew Read argues for new treatment strategies in race against rapidly evolving 'bugs.'
Doctors Without Borders nurse brings her experience to Penn State MOOC Doctors Without Borders nurse brings her experience to Penn State MOOC The 2014 Epidemics MOOC brings together a worldwide audience to discuss the ongoing Ebola outbreak.
Job Opportunities
[···] — Posted Aug 04, 2015
Research Fellow @ University of Michigan This is a collaborative project between the labs of Robert Woods at the University of Michigan and Andrew Read at Pennsylvania State University. The position will be based at the University of Michigan, with some time spent at the Center of Infectious Disease Dynamics at Penn State. — Posted May 20, 2015
Postdoctoral Research Associate Department of Biology, Georgetown University, Washington DC, USA — Posted Feb 06, 2015
Postdoctoral Scholar: Disease transmission in societies — Posted Dec 03, 2014
Postdoctoral Position in Bacterial Pathogenesis, Host and Microbiota — Posted Nov 26, 2014
Postdoctoral Scholar in Molecular Parasitology — Posted Mar 15, 2015
Highlights from recent research
Leaky vaccines promote the transmission of more virulent virus Leaky vaccines promote the transmission of more virulent virus Recent work by CIDD researcher Andrew Read and colleagues has shown that leaky vaccines can facilitate the evolution of more virulent pathogens. Leaky vaccines prevent the symptoms of disease without preventing transmission. By prolonging host survival, leaky vaccines allow highly virulent pathogens to persist when they ordinarily would kill hosts too rapidly to transmit.
Immune response and insulin signalling alter mosquito feeding behaviour to enhance malaria transmission potential Mosquitoes undergo behavioral changes during malaria infection that are thought to increase transmission of the parasites. Infected mosquitoes are more likely to host seek and persistently feed during the most infectious stage of parasite development compared to uninfected mosquitoes or mosquitoes infected during earlier non-infectious stages. Recent work by Lauren Cator and CIDD colleagues Courtney Murdock, Johanna Ohm, Matt Thomas and Andrew Read has demonstrated that the mechanism behind these behavioral changes is related to insulin signaling pathways in the mosquito midgut.
Measuring population movement during a crisis with cell-phones and satellites Measuring population movement during a crisis with cell-phones and satellites CIDD researcher Nita Bharti combines cell phone data and satellite nightlight imagery collected during a period of political conflict to remotely measure population movement across spatial and temporal scales.
Cytotoxic T lymphocytes modulate outcomes for patients receiving antiretroviral therapy for HIV Cytotoxic T lymphocytes modulate outcomes for patients receiving antiretroviral therapy for HIV Some patients are able to control HIV infections even after cessation of antiretroviral therapies, but the mechanisms allowing for this post-therapeutic control remain unclear. In a recent paper published in PNAS, CIDD researcher Jessica Conway and Alan Perelson from the Los Alamos National Laboratory explore the mechanisms that allow for post-treatment HIV control. The team shows that antiretroviral treatment outcomes may depend on a balance between the size of the reservoir of latently HIV-infected cells and how effectively the patient’s cytotoxic T lymphocytes (CTLs) control emerging HIV infection. By varying CTL efficacy and size of the latent HIV reservoir, their model reproduced the full range of observed post-infection HIV outcomes: post-treatment control, post-treatment viral rebound and re-establishment of infection, and natural pre-treatment control by patients known as ‘elite controllers’.
A humanized mouse model for Plasmodium vivax liver stage A humanized mouse model for Plasmodium vivax liver stage Recent work by CIDD researcher Scott Lindner and colleagues has demonstrated a successful new model system for studying a species of human malaria parasites that previously evaded researchers’ attempts to study the parasites in vivo: Plasmodium vivax. Vivax malaria has historically been less studied than malaria caused by another human malaria parasite, P. falciparum, despite P. vivax’s longer persistence and higher prevalence in Asia and South America. The successful new humanized mouse model developed by Lindner and colleagues should help to shift attention to increase research on drug treatments and liver stage development of this important parasite. Excitingly, this model also supports investigations of an elusive dormant form of the parasite, called a hypnozoite, that causes relapses months or years after the primary infection occurs. Now that we can study this stage of the parasite, we can begin to understand it. The development of the model was published in a recent edition of Cell Host & Microbe.
» More Highlights from recent research
Millennium Science Complex

Millennium Science Complex as viewed from Pollock Field.

Many CIDD faculty and their research groups have re-located to Penn State’s new Millennium Science Complex. This is a state-of-the art research facility which will become the gateway for interdisciplinary research between the Life Sciences and the Material Sciences’ faculty and students.

Find out more about the building.

From proteins to pandemics

CIDD brings together scientists in a range of complementary disciplines to innovate in infectious disease research.

More about CIDD

Upcoming events

CIDD seminars are publicized on the Huck Institutes website

Monday discussions are held every Monday at 12pm in W-203 Millennium Science Complex

 
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