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Eddie Holmes

Eddie Holmes

Professor in Biology
Eberly College of Science Distinguished Senior Scholar

Emailech15@psu.edu

Phone: 814-863-4689

Office: 609 Mueller Lab

Research interests

My research integrates ideas from a number of different fields, most notably evolutionary genetics, virology and the epidemiology of infectious disease. I am currently concentrating on three main areas, using RNA virus study systems.

Evolutionary genetics

I am investigating questions such as:

  • The roles played by mutation, natural selection, recombination, and gene flow in shaping patterns of genetic diversity on RNA viruses.
  • The evolutionary factors that underpin the process of cross-species virus transmission (i.e. of viral emergence).

Comparative genomics

My work in this area includes:

  • Understanding the factors that have generated the diversity of genome structures and organizations observed in RNA viruses.
  • Revealing the origins of RNA viruses and particularly how they relate to the early 'RNA-protein' world.

Molecular epidemiology

Much of my research in this area fits within the emerging discipline of phylodynamics.

  • Understanding the patterns and processes of evolutionary change in such key human viruses as influenza and dengue.
  • Collaborative experimental studies on the intra- and inter-host evolution of influenza viruses and parvoviruses.
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